This Report presents a Caribbean-led agenda to address climate change’s growing health impacts, identifying 18 priority action areas and evidence-based recommendations to strengthen health systems, close research gaps, and accelerate coordinated, resilient responses across the region. It was produced with financing from the Caribbean Development Bank under the Strengthening Institutional Capacity for a Resilient Caribbean Coastal and Marine Environment (RCCAME) project through the Caribbean Action for Resilience Enhancement (CARE) Programme.